Usual Dose & Administration
Usual Adult Dose
875 mg PO q12h
Adjustment of Dose & Administration
Indication-Specific Adjustment
|
Indication |
CrCl (mL/min) |
|||
|
>30 |
10 - 30 |
<10, IHD |
CRRT |
|
|
UTI, skin and soft tissue infection, sinusitis, pneumonia, otitis media |
875 mg q12h |
500 mg q12h |
500 mg q24h (give after dialysis) |
875 mg q12h |
|
Bloodstream infection (e.g. E. coli BSI), Bone and Joint Infection |
875 - 1000 mg q8h |
500 mg q8h |
500 mg q12h (give after dialysis) |
875 mg q8h |
Drug-Specific Information
Tablet strengths:
Amoxicillin 875 mg- Clavulanate 125 mg
Amoxicillin 500 mg- Clavulanate 125 mg
Amoxicillin 250 mg- Clavulanate 125 mg
Cost Index
$ (1-10)
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.